I move about Toronto using the TTC (Toronto Transit Commission). For the most part, it serves me well. No need for a car; especially where I live: The Annex neighbourhood.
Living close to downtown also makes for a nice walk to the city centre if I decide to stay above-ground during my trip.
What can't be forgotten is this area is well-served by the subway. The University-Spadina and the Bloor-Danforth lines make a nice cross.